Chris from Tech2C YT channel made a video showing various settings on his EleksMaker 2.5w laser diode for cutting a 3mm Acrylic sheet. It is mounted on HyperCube 3D printer.
It is an interesting video if you want to go into lasing acrylic with a cheap laser diode and you want to learn something and save some experimentation time.
Tip from the comments: black acrylic is easiest to cut since it absorbs the most energy.
HyperCube 3D Printer/CNC on Thingiverse: